What Went Wrong:
The Truth Behind the Clinical Trial of the Enzyme Treatment of Cancer
Nicholas J. Gonzalez, MD
The Battle for a Fair Evaluation of the Gonzalez Therapy
Also available through Amazon
Published July 2012
Hard cover: 600 pages including references
Product dimensions: 7 x 10 inches
In this book, Dr. Nicholas Gonzalez exposes what went wrong with the clinical trial "Pancreatic proteolytic enzyme therapy compared with gemcitabine-based chemotherapy for the treatment of pancreatic cancer," sponsored by the National Center for Complementary and Alternative Medicine and the National Cancer Institute, conducted under the auspices of Columbia University.
- Reports Dr. Gonzalez’s first-hand account of bias at the highest levels of the academic research world, which helped undermine the project.
- Examines how poor trial design and implementation condemned this project to failure.
- Reveals how two government oversight offices confirmed Dr. Gonzalez’s claims of mismanagement by the study supervisors.
Read the Introduction, the Table of Contents, a Foreword by a patient (150 KB), Reviews, About the Author, and an article adapted from a portion of the book, Some Thoughts about Scientific Bias
From the Back Cover:
Kilmer McCully, M.D., author of The Heart Revolution:
“For all who are interested in the pioneering studies of Gonzalez and Isaacs on the nutritional and metabolic control of cancer, their new book What Went Wrong is highly recommended. This extraordinary story paints a detailed picture of mismanagement of a promising clinical trial of pancreatic cancer therapy by vested interests of the National Cancer Institute, the National Institutes of Health, and Academia. The story is one of conviction, persistence and dedication in the face of opposition by the cancer industry.”
Paul J. Rosch, M.D., President, The American Institute of Stress:
“This book is about a $1.4 million grant awarded by the National Cancer Institute in 1998 to do a controlled clinical trial comparing the chemotherapeutic drug Gemzar to Dr. Gonzalez’ enzyme approach in the treatment of patients with pancreatic cancer. Dr. Gonzalez documents how the study was mismanaged, how he had no control over the selection of patients, and how the protocol was violated in numerous ways that were subsequently confirmed by regulatory authorities. Yet, a misleading article was published without his knowledge and none of the responsible parties were ever admonished or held accountable. This tragic tale tends to support a growing suspicion that the cancer cartel of organizations, government agencies and vested interests is devoted more to preserving their enormous profits and reputations than to the prevention and cure of cancer.”
Suzanne Somers, actress and author:
“This is a story that truly needed to be told. In this important book, Dr. Gonzalez carefully details his serious well-intentioned attempt to have his nutritional approach to cancer properly tested in a National Cancer Institute clinical trial, only to have the project mismanaged by the academic and government scientists in charge. It is a tale of indifference, indifference to scientific truth and indifference to patient well-being that reached right into the highest levels of the cancer research world. It shows first hand the strong biases against natural therapies among the powers that be that keep useful treatments like his from seeing the light of day. For those with an interest in alternative medicine, and particularly for those who still have faith in the integrity of our conventional medical authorities, this book will be an eye-opener.
“Nick Gonzalez is a wonderfully knowledgeable, completely dedicated, idealistic physician. For my book Knockout I interviewed many of his patient successes who have conquered terrible cancer with his treatment, so I know the regimen works. Hopefully, this book will finally set the record straight about the NCI clinical trial and help get this researcher the credit he deserves.”
“Reading What Went Wrong reminded me of the statement - the less the people know about how sausages and laws are made, the better they sleep in the night. One need only exchange the words ‘laws’ with ‘CAM research’ to understand my perspective. To date, few in the CAM community have been willing to wake up and enter into the fray of discussing an egregious miscarriage of justice for the pancreatic cancer community and for the future of honest dialogue about CAM research. …
“While What Went Wrong is a long read (more than 500 pages), it is organized in logical fashion and separated into 44 chapters. As one learns in this book, this is not the story of a single error in management of the study, but a series of violations of protocol, ethics, and law. …
“This is an essential read for everyone interested in CAM research.” Beth Clay, former NIH and US Congress staffer, in The Integrator Blog
“I highly recommend What Went Wrong. … Gonzalez's book shows us the deeply rooted institutional backlash that infuses the study of an effective, individualized, nonconventional therapy … . His experience is a shot across the bow of all nonconventional practitioners who strive to see their methods authentically evaluated and validated. It is a contemporary history that we would all be wise to study.” Greg Nigh, N.D., L.Ac., in Natural Medicine Journal, the official journal of the American Association of Naturopathic Physicians
“This book is alternately depressing, infuriating and inspiring.” Miriam Knight, editor, New Consciousness Review
“As Dr. Gonzalez reveals in his book What Went Wrong: The Truth Behind the Clinical Trial of the Enzyme Treatment of Cancer, poor trial design, poor implementation at the highest levels of the research, and improper supervision in the trial itself completely derailed the study.
“The book also calls into question the validity of double-blind placebo studies as the gold standard of mainstream medicine. Dr. Gonzalez delves into biases of scientific health community that make the fair testing of unconventional treatments so difficult. …
“Dr. Gonzalez’s experience is a testament to the failure of mainstream medicine.” Alliance for Natural Health USA
“What Went Wrong: The Truth Behind the Clinical Trial of the Enzyme Treatment of Cancer excoriates the horrendous mismanagement and subsequent cover-up of a National Cancer Institute/National Institutes of Health clinical trial to study author Nicholas J. Gonzalez, M.D.'s nutritional treatment methods for patients diagnosed with inoperable pancreatic cancer. … The therapy was not properly evaluated or analyzed despite years of so-called research, depriving future cancer patients accurate information about all their treatment options. What Went Wrong is a striking case study of a scientific study gone terribly awry, and highly recommended for science and medical professionals as well as for concerned laypeople.” The Midwest Book Review
About the Author:
Nicholas J. Gonzalez, M.D.
Nicholas J. Gonzalez, M.D., graduated from Brown University, Phi Beta Kappa, magna cum laude with a degree in English Literature. He worked as a journalist, first at Time Inc., before pursuing premedical studies at Columbia University. He received his medical degree from Cornell University Medical College in 1983. During a postgraduate immunology fellowship under Dr. Robert A. Good, considered the father of modern immunology, Dr. Gonzalez investigated the nutritional cancer treatment developed by the dentist Dr. William Donald Kelley. Dr. Gonzalez’s subsequent research has been funded by The Procter & Gamble Company, Nestlé, and the National Cancer Institute/National Institutes of Health. Since 1987, Dr. Gonzalez has been in private practice in New York City, treating cancer and other degenerative diseases with an enzyme-based nutritional regimen. He is in the process of publishing a series of books, of which What Went Wrong is the third. For more information on his practice or his books, see his website.
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